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Important fabrication issues such as achieving high dimensional resolution and ability to control distortion due to shrinkage are presented and discussed.The operational performance of both multi-photon and CAD-created models under steady blood flow conditions was evaluated and compared through computational fluid dynamics analysis.It was possible to achieve 80% porosity corresponding to about 150 cm surface area) and with a channel to channel distance of only 78 μm.To our knowledge this is the largest scaffold ever to be produced with such small feature sizes and with so many structured channels.The PVA mould network defines the channels and is dissolved after curing the polymer casted around it.

The person does this automatically, without thinking, by innervating their ciliary body muscle in the eye.The fabricated scaffolds were applied for in-vitro culturing of hepatocytes over a 12-day culture period.Smaller scaffolds (6 × 4 mm) were tested for cell culturing and could support homogeneous cell growth throughout the scaffold.: We report on the design, modeling and fabrication by multi-photon polymerization of a complex medical fluidic device.The physical dimensions of the built micro-valve prototype are compared to those of its computer-designed model.




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